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Saliva Help Early Diagnosis of Oral Cancer

Posted on June 21st, 2010 under General Health. Post a comment

oral cancer testA study by U.S. scientists, whose findings were published in the online edition of the journal Clinical Cancer Research 25 August, found that saliva contains at least 50 microRNAs, which would help in the detection of oral cancer.

The microRNAs are molecules that control the activity and evaluate the behavior of multiple genes, according to background information in a press release on the study of the American Association for Cancer Research (American Association for Cancer Research.)

In the study, researchers measured the levels of microRNAs in the saliva of fifty patients with oral squamous cell carcinoma and fifty healthy people, and identified at least 50 microRNAs that could be related to oral cancer.

The researchers found that levels of two of them, miR-miR-125th and 200th, were significantly lower among cancer patients than among healthy people.

Dr. David T. Wong, study author and professor at the Faculty of Dentistry, University of California at Los Angeles, said in a press release that “the oral cavity is a mirror of systemic diseases” and that “many diseases that develop in other body sites have spoken. ”

The study’s findings must be confirmed by more in larger and longer, according to Wong.

For his part Dr. Jennifer Grandis, a professor of otolaryngology and pharmacology at the Faculty of Medicine and Cancer Institute of the University of Pittsburgh and principal editor of Clinical Cancer Research, said “It is the corner stone of cancer detection to measure the presence of cancer without biopsy, which is very attractive to think that we could detect a specific marker of cancer in the patient’s saliva.” [photo by thedoctorstv]

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