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Inflammatory Breast Cancer, a Rare and Aggressive Variant

Posted on June 16th, 2010 under General Health. Post a comment

Inflammatory Breast CancerIt is a kind of strange and extremely malignant cancer that is often confused with minor medical problems, preventing the early detection of disease. Inflammatory breast cancer, a type of cancer is extremely malignant strange as it may develop into metastases in just a few weeks. The disease is usually detected more frequently in women between 45 and 55 years of age.

All aspects of the treatment of inflammatory breast cancer including staging, diagnosis and therapy, totally different from the other types of breast cancer. Often tends to confuse the inflammatory breast cancer with minor medical problems such as a rash or a breast infection, which often prevents the early detection of disease that requires immediate diagnosis to save lives.

Other tumors usually present as a lump, but inflammatory breast cancer spreads throughout the breast tissue, making the disease difficult to detect with a mammogram.

Statistics of inflammatory breast cancer

The inflammatory breast cancer represents between 1 and 2 percent of invasive breast cancers diagnosed in developed countries.

In the United States, accounts for 3 to 6 percent of the 180,000 women diagnosed with breast cancer in that country.

Life expectancy for someone with the disease was from 5 to 10 percent 20 years ago. However, at present, with proper treatment, the median survival rate five years after diagnosis is approximately 40 percent.

Most patients experience relapse at distant sites. A 20 to 40 percent of patients survive 10 years.

Symptoms

Inflammatory breast cancer is a very aggressive type of cancer. Cancer cells move quickly across the chest, blocking the lymph vessels in the skin and causing the following symptoms: swelling, warmth in the breast, redness, purple or bruised, and skin for lumps or similar marks on the skin of an orange.

They may also be other symptoms such as pain, tenderness, burning, increased breast size and inverted nipple.

The good news is that scientists from the New York University School of Medicine, have identified the factors that cause inflammatory breast cancer, which raises hopes that a successful therapeutic intervention, to stop the spread of this variant particularly aggressive breast cancer, experts say.

The results were recently published in the latest issue of the journal Nature, reporting that the overabundance of a protein identified as eIF4GI, makes the cancer cells become more adhesive and more rapidly in metastatic tumors.

The U.S. University team led by Professor Robert Schneider found that while eIFG4GI regulator protein did not affect the entire production of other proteins, it resulted in higher levels of regulators of cell adhesion E-cadherin and p120 catenin.

These regulatory environment that cancer cells are grouped together, instead of sticking to surrounding tissues, so that cells can be grouped into the bloodstream and spread throughout the body, in a process known as metastasis passive responsible for the high mortality of inflammatory breast cancer

Treatment

Treatment of inflammatory breast cancer often involves a multi-modality therapy. Includes: aggressive chemotherapy followed by surgery and radiation therapy.

Women with red and swollen breasts that do not subside with antibiotic treatment should be assessed to rule out the possibility of inflammatory breast cancer, which can be lethal.

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